Initiated Phase IIb clinical trial of AFN0328, a therapeutic mRNA vaccine for HPV-associated HSIL

Completed Phase II clinical trial of AFN0205, an RSV mRNA vaccine candidate

Completed Series A financing to advance RNA therapeutics and immune engineering platforms

Published breakthrough findings on systemic regulation of drug delivery in Science

Published discoveries on tumor vascular transport mechanisms in Nature Nanotechnology

Published a data-driven organ-selective mRNA delivery platform in Journal of the American Chemical Society

Publication in Nature Biomedical Engineering (Our Innovative Breakthrough: Generating Tolerogenic Antigen-Presenting Cells in Vivo)

Completion of Pre-A3 round financing

Start of Phase 2 clinical trial for RSV mRNA vaccine

First human dose of Herpes zoster mRNA vaccine

First human dose of an individualized neoantigen-based mRNA vaccine for metastatic/ R/R solid tumor

7 National Key R&D Programs Secured to date, funded by the Ministry of Science and Technology (MOST), National Natural Science Foundation of China (NSFC) and the National Health Commission (NHC)

Completion of Pre-A2 round financing

Established a subsidiary in Shanghai

First human dose of RSV mRNA vaccine

First human dose of Therapeutic HPV mRNA vaccine for cervical High-grade Squamous Intraepithelial Lesion (HSIL)

Publication in Molecular Therapy

4 National Key R&D Programs secured under the direct sponsorship of the National Laboratory and the Ministry of Science and Technology (MOST)

Completion of Pre-A1 round financing

Received clinical trial approval for a COVID-19 mRNA vaccine targeting the Omicron variant

Funded by National Key R&D Programs led by the Ministry of Science and Technology of China

Publication in Cell research

Recognized as National High-Tech Enterprise

Establishment of a comprehensive platform (TALENT^®) to enable design, proof of concept and preclinical validation, scalable manufacturing of mRNA-based medicines

Established a new company with Anhui Anke Biotechnology (Group) Co., Ltd.

Founded in the district of Economic and Technological development, Hefei, Anhui

Completion of Angel round financing